Continuum mathematical models for collective cell motion normally involve reaction-diffusion equations, such as the Fisher-KPP equation, with a linear diffusion term to describe cell motility and a logistic term to describe cell proliferation. While the Fisher-KPP equation and its generalisations are commonplace, a significant drawback for this family of models is that they are not able to capture the moving fronts that arise in cell invasion applications such as wound healing and tumour growth. An alternative, less common, approach is to include nonlinear degenerate diffusion in the models, such as in the Porous-Fisher equation, since solutions to the corresponding equations have compact support and therefore explicitly allow for moving fronts. We consider here a hole-closing problem for the Porous-Fisher equation whereby there is initially a simply connected region (the hole) with a nonzero population outside of the hole and a zero population inside. We outline how self-similar solutions (of the second kind) describe both circular and non-circular fronts in the hole-closing limit. Further, we present new experimental and theoretical evidence to support the use of nonlinear degenerate diffusion in models for collective cell motion. Our methodology involves setting up a two-dimensional wound healing assay that has the geometry of a hole-closing problem, with cells initially seeded outside of a hole that closes as cells migrate and proliferate. For a particular class of fibroblast cells, the aspect ratio of an initially rectangular wound increases in time, so the wound becomes longer and thinner as it closes; our theoretical analysis shows that this behaviour is consistent with nonlinear degenerate diffusion but is not able to be captured with commonly used linear diffusion. This work is important because it provides a clear test for degenerate diffusion over linear diffusion in cell lines, whereas standard one-dimensional experiments are unfortunately not capable of distinguishing between the two approaches.
A spectrogram is a useful way of using short-time discrete Fourier transforms to visualise surface height measurements taken of ship wakes in real world conditions. For a steadily moving ship that leaves behind small-amplitude waves, the spectrogram is known to have two clear linear components, a sliding-frequency mode caused by the divergent waves and a constant-frequency mode for the transverse waves. However, recent observations of high speed ferry data have identified additional components of the spectrograms that are not yet explained. We use computer simulations of linear and nonlinear ship wave patterns and apply time-frequency analysis to generate spectrograms for an idealised ship. We clarify the role of the linear dispersion relation and ship speed on the two linear components. We use a simple weakly nonlinear theory to identify higher order effects in a spectrogram and, while the high speed ferry data is very noisy, we propose that certain additional features in the experimental data are caused by nonlinearity. Finally, we provide a possible explanation for a further discrepancy between the high speed ferry spectrograms and linear theory by accounting for ship acceleration.
A spectrogram of a ship wake is a heat map that visualises the time-dependent frequency spectrum of surface height measurements taken at a single point as the ship travels by. Spectrograms are easy to compute and, if properly interpreted, have the potential to provide crucial information about various properties of the ship in question. Here we use geometrical arguments and analysis of an idealised mathematical model to identify features of spectrograms, concentrating on the effects of a finite-depth channel. Our results depend heavily on whether the flow regime is subcritical or supercritical. To support our theoretical predictions, we compare with data taken from experiments we conducted in a model test basin using a variety of realistic ship hulls. Finally, we note that vessels with a high aspect ratio appear to produce spectrogram data that contains periodic patterns. We can reproduce this behaviour in our mathematical model by using a so-called two-point wavemaker. These results highlight the role of wave interference effects in spectrograms of ship wakes.
While the half-angle which encloses a Kelvin ship wave pattern is commonly accepted to be 19.47 • , recent observations and calculations for sufficiently fast-moving ships suggest that the apparent wake angle decreases with ship speed. One explanation for this decrease in angle relies on the assumption that a ship cannot generate wavelengths much greater than its hull length. An alternative interpretation is that the wave pattern that is observed in practice is defined by the location of the highest peaks; for wakes created by sufficiently fast-moving objects, these highest peaks no longer lie on the outermost divergent waves, resulting in a smaller apparent angle. In this paper, we focus on the problems of free surface flow past a single submerged point source and past a submerged source doublet. In the linear version of these problems, we measure the apparent wake angle formed by the highest peaks, and observe the following three regimes: a small Froude number pattern, in which the divergent waves are not visible; standard wave patterns for which the maximum peaks occur on the outermost divergent waves; and a third regime in which the highest peaks form a V-shape with an angle much less than the Kelvin angle. For nonlinear flows, we demonstrate that nonlinearity has the effect of increasing the apparent wake angle so that some highly nonlinear solutions have apparent wake angles that are greater than Kelvin's angle. For large Froude numbers, the effect on apparent wake angle can be more dramatic, with the possibility of strong nonlinearity shifting the wave pattern from the third regime to the second. We expect our nonlinear results will translate to other more complicated flow configurations, such as flow due to a steadily moving closed body such as a submarine.
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