Small vessel disease (SVD) in the brain manifests in the periventricular and deep white matter and radiographically is described as "leukoaraiosis". It is increasingly recognized as a cause of morbidity from middle age onward and this clinical relevance has paralleled advances in the field of neuroradiology. Overall, SVD is a heterogenous group of vascular disorders that may be asymptomatic, or a harbinger of many conditions that jeopardize brain health. Management and prevention focuses on blood pressure control, lifestyle modification, and symptomatic treatment.

Catatonia is a movement disorder with various possible etiologies. The majority of cases are associated with an underlying mood or psychotic disorder, while others are caused by medical conditions. Currently, benzodiazepines are the first-line psychopharmacologic agents in the treatment of catatonia. However, several cases have been reported in which treatment with memantine proved to be effective. We present the case of a 92-year-old female with major depressive disorder and associated catatonic symptoms. In this case, the patient's symptoms remitted quickly after the initiation of memantine. We review the possible causes of catatonia and pharmacologic treatments for the condition and highlight the possible benefits of N-methylD-aspartic acid receptor antagonists such as memantine in the treatment of catatonia.

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On page 6, an error was made in the Conflict of Interest. The correct Conflict of Interest should be the following:Christian Schenk and Timothy Wuerz declare that they have no conflict of interest.Alan J. Lerner has been a consultant for Eli Lilly and Siemens; has given expert testimony for Easton and Smith, and Wulliger, Fadel, and Beyer; and has received royalties from Elsevier and Springer. He also has received grant support from Baxter Labs and Ceregene in association with ADCS; and has received travel/accommodations expenses covered or reimbursed from NIH-sponsored grant-related meetings.The online version of the original article can be found at http://dx