In 2020 the whole world was faced with an epidemiological outbreak caused by a new coronavirus SARS-CoV-2. The information available to date suggests that the newly isolated SARS-CoV-2 coronavirus should be assigned to superantigens, the main manifestations of which, as it is known, are suppression of nonspecific resistance factors and suppression of innate immunity mechanisms associated with the formation of a systemic inflammatory response in the form of cytokine storm and pathological activation of phagocytes in the lung tissue with its alteration and subsequent fibrosis. In this case, it is quite difficult and sometimes even impossible to observe the formation of fully-fledged specific immune answer on the effect of such antigens. This, along with the high infectious nature of the disease and the associated mortality, requires special attention to the underlying immunopatomechanism(s). Perhaps that is why little information has been obtained regarding the immunogenic properties of the newly isolated SARS-CoV-2 coronavirus so far, as well as, most importantly, about the structures of the virus itself responsible for the formation of specific immunity to it. The latter will serve as the basis for patient management and vaccine development. Nevertheless, a certain point of view on this issue is already beginning to form, as tools for detecting specific antibodies are being actively developed, as well as modern diagnostic tests for coronavirus, which include real-time polymerase chain reaction, real-time reverse transcription polymerase chain reaction and isothermal amplification mediated by reverse transcription. The presented analysis makes it possible to expand the understanding of the issue concerning the immunopathogenesis of COVID-19, the mechanisms of the onset and development of the disease in a living organism, the formation of an immune response to the new coronavirus, and also to determine the therapeutic tactics of managing patients with severe coronavirus infection. Elucidating the mechanisms of the emergence and development of a new coronavirus infection can help scientists, general practitioners, clinicians, and laboratory physicians respond correctly to the COVID-19 pandemic.

The study investigated the dynamics of class G immunoglobulins to severe acute respiratory syndrome-2 coronavirus in the blood serum of convalescents who had a new coronavirus infection for 6 months after the polymerase chain reaction conversion. Among the most common symptoms, 30 (73.8%) convalescents had an increase in body temperature to 38C, 32 (83.3%) had asthenia, 21 (59.5%) had cough, 29 (73.8%) had perversion or loss of sense of smell, pain, and throat discomfort. The duration of symptoms varied from 34 days to 34 weeks. Within a month after the end of the acute disease period, 8 (20%) patients had a decrease in working capacity, 13 (33%) had difficulty breathing, 9 (22%) had a cough, and 4 (10%) had pain and sore throat. During severe acute respiratory syndrome 2 infection, the virus activates the innate and adaptive immunity, resulting in the formation of specific class G immunoglobulins to the pathogens. After leveling the clinical manifestations, class G immunoglobulins were detected in the majority of convalescents (79%90%) during the first 6 months, starting from day 14 from disease onset with a predominantly high ( 10 conl. units) positivity coefficient. Moreover, this pattern occurred in both men and women; however, in some studies, the levels of the positivity coefficient of class G immunoglobulins began to decrease by the fifth month of follow-up and sometimes at an earlier time (2 months). Perhaps, this is due to the different functional activities of the immune system of each convalescent, infecting dose of the pathogen, and peculiarities of its interaction with the macroorganism and its immune system. Nevertheless, the class G immunoglobulins identified in the study do not yet indicate the probability of reinfection of convalescents with the same pathogen. The protective titer of antibodies has yet to be investigated further.

Introduction. Currently, there is an increasing need for the study and development of the World Ocean, including for the purpose of laying deep-water pipelines, searching for new sources of minerals, etc. The performance of special tasks by divers at great depths has its own characteristics. The high cost of error, harmful working conditions - all this dictate the need for continuous receipt and analysis of scientific material on the preservation and promotion of health, ensuring their longevity, as well as the adaptation of divers to the nature and conditions of professional activity in order to prevent the occurrence of errors. The study aims to explore the functions of attention and thinking of a person, his fine muscular coordination and subjective assessment of the state of the body of divers, as elements of the functional state of the body, when working underwater. Materials and methods. We examined 18 divers, divided into two groups: the first - ten people made daily descents to a depth of 18 m, the second group - eight people dived to a depth of 56 m. Before and after diving, the divers underwent a psychophysiological examination to assess the function of attention (the method of the correction test with Landolt rings), the function of thinking (the method of the arithmetic test "addition in mind"), fine muscle coordination (the method of macrography) and subjective assessment of the state (the SAN questionnaire (state of health - activity-mood)). Results. During diving operations, there was a decrease in subjective self-assessment of the state of the body (SAN test), an increase in the number of errors (correction test with Landolt rings - attention function) and the values of the height index of numbers (macrography technique - fine muscle coordination), a decrease in the speed of thinking depending on the depth, the multiplicity of diving descents, as well as the dive itself (regardless from depth and multiplicity) on the functional state of divers. There were most pronounced changes during prolonged work (3-5 days or more) and when diving to a depth of 56 m. Conclusion. The dynamics of objective indicators and subjective assessment of the state of the body indicates that with an increase in the depth of immersion (from 18 to 56 m), the multiplicity of diving descents (daily immersion for 5 days) and the dive itself, the self-esteem of the state, the speed of thinking, attention, fine muscle coordination decreases. Ethics. The study was conducted in compliance with the Ethical principles of conducting medical research with human participation as a subject, set out in the Helsinki Declaration of the World Medical Association.