Isoxazoline analogues of artemisinin were obtained in low yield and low diastereoselectivity from the 1,3-dipolar cycloaddition of nitrile oxides. Alternatively, starting from the aldehyde 7, a number of transformations -Wittig reaction and reduction, Henry reaction and cyanohydrin formation -were achieved in significantly higher yields. In the cases where a new stereocenter was introduced this occured diastereoselectively.
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