Incontinentia pigmenti (IP) is a rare neuroectodermal dysplasia caused by mutations in the IKBKG gene. We present a case of a 4-month-old female infant with erythematous vesicular skin lesions on the trunk and extremities. Histopathologic examination of the blisters revealed an eosinophilic infiltrate. Further investigation revealed that her mother had three unexplained miscarriages and two normal uncomplicated pregnancies, resulting in the birth of two male infants. We performed a comprehensive genetic evaluation to rule out the interference of pseudogene IKBKGP, and the infant was finally diagnosed with IP. During the subsequent 2-year follow-up, we observed a significant improvement in her dermatologic symptoms, with no evidence of recurrence, and there were no other associated symptoms in the hair, nails, oral mucosa, eyes, or central nervous system.

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Eczema is a common non-communicable skin disease that has been around us for a long time. While the current protocols for treating eczema only focus on the part of the skin, the mostly used corticosteroids and palliative medications are often resulting in numerous side effects. Traditional Chinese Medicine (TCM) can therefore provide an alternative treatment for the disease, using the novel approach of the Liver-Skin axis relationship. Here we provide a case of an 11-year old girl who was treated using TCM with clearing liver and detoxing. With the use of a renowned TCM prescription, Long Dan Xie Gan Tang, chronic eczema was successfully controlled and even completely cured. In the present study, our clinical evidence was also complementary to the preceding clinic of Chinese Society; we suggest a novel therapy for eczema on reducing heat and detoxing of the liver by 'liver-skin axis' for the first time, which may play positive roles in treating eczema patients.