Susceptibility-weighted imaging is useful in differentiating and characterizing diverse brain pathologies.

Endovascular treatment of direct CCFs is safe and effective and results in long-term cure.

Three-dimensional (3D) constructive interference in steady state (CISS) is a gradient-echo MRI sequence that is used to investigate a wide range of pathologies when routine MRI sequences do not provide the desired anatomic information. The increased sensitivity of the 3D CISS sequence is an outcome of the accentuation of the T2 values between cerebrospinal fluid (CSF) and pathological structures. Apart from its well-recognized applications in the evaluation of the cranial nerves, CSF rhinorrhea and aqueduct stenosis, we have found the CISS sequence to be useful for the cisternal spaces, cavernous sinuses and the ventricular system, where it is useful for detecting subtle CSF-intensity lesions that may be missed on routine spin-echo sequences. This information helps in the management of these conditions. After a brief overview of the physics behind this sequence, we illustrate its clinical applications with representative cases and discuss its potential role in imaging protocols.

The authors' experience in evaluation and management of VGMs reveals that in areas of the world where access to dedicated specialist care is limited, the clinical presentation of VGMs can differ appreciably from the classic descriptions in the literature. Endovascular management of these lesions results in excellent angiographic and clinical results.

SUMMARYAim: Dedicated magnetic resonance imaging (MRI) protocol can diagnose epileptogenic abnormalities in patients with intractable epilepsy. However, it is not sufficiently sensitive to detect small calcified lesions that may result from infections, tumors, or vascular malformations. This study aims to study the impact of the addition of T2*gradient echo/susceptibility weighted imaging (T2*GRE/SWI) sequence to a dedicated MRI protocol. Method: One hundred thirty-seven patients with intractable epilepsy underwent MRI using conventional epilepsy protocol with addition of T2*GRE/ SWI sequence. Comparison of the images with and without these sequences was done for detection of calcified abnormalities/vascular abnormalities. In patients with calcified lesions, MRI findings were correlated either with histopathology or computerized tomography (CT) to confirm the presence of calcification.Results: In 16 patients the sequence gave additional information compared to conventional imaging protocol. The sequence helped in better characterization of lesions in all patients. In three patients it helped in detecting the lesion and in another three it appeared useful as it best characterized the lesions. Additional lesions were detected in two patients with old calcified granulomas. Important additional information was supplied in four patients, whereas in the remaining patients lesion conspicuity was increased. Conclusion: T2*GRE/SWI sequence should form part of routine epilepsy protocol as it increases sensitivity by detecting occult calcified lesions or vascular malformations that may be responsible for the patient's seizures. This is especially important in patients from developing countries who have post-infective calcified lesions responsible for seizures and who undergo only MRI as the imaging modality for intractable seizures.