The aim of the research were to evaluate the efficacy of botanical insecticide of Swietenia mahagoni leaves extracts against larvae of Aedes aegypti, based on concentration of the leaves S. mahagoni extract, and in additional to determine secondary metabolites compounds of S. mahagoni leaves extract. The extraction of S. mahagoni leaves was done by using ethanol solvents and than was analyzed by using Thin Layer Chromatography. The result indicated that ethanolic extract of S. mahagoni leaf contained alkaloid, tannin, saponin, terpenoid, and flavonoid compounds. The value of LC 50 and LC 90 calculation showed that LC 50 of ethanolic extract over second and third instar larvae respectively were 488 ppm and 644 ppm. However the value of LC 90 of both instar larvae were 732 ppm and 797 ppm. Based on the above result, it can be concluded that ethanolic extract of S. mahagoni leaf was effective against larvae of Ae .aegypti.