Healthcare workers in hospitals are vulnerable to risks associated with solid medical waste, such as used unsterile needles. This study aims to explain the relationship between knowledge with attitudes and behavior of students and solid medical waste knowledge. This was a descriptive-analytic study with consecutive sampling method, conducted from June to December 2018 on students of the medical professional education program at the Universitas Sumatera Utara Hospital. A questionnaire was performed to test the data validity and reliability, whereas the data was statistically analyzed using the Fisher Exact test. A total of 50 students consisting of 31 women (62%) and 19 men (38%), the majority were aged 22-23 years as many as 40 students (80%). On average, 26 students (52%) had a moderate level of knowledge, but more students had good attitudes and behaviors, that is 39 people (78%) and 33 people (66%), respectively. There is no relationship between knowledge about solid medical waste with the attitudes and behavior of students in the medical professional education program, with p-values = 0.227 (p> 0.05) and p-values = 0.217 (p> 0.05), respectively.
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