Hallermann–Streiff syndrome (HSS), an asymmetric second branchial arch defect affects growth, cranial and dental development. A 40-year-old lady with HSS developed severe pain and redness in her right eye due to raised intraocular pressure (IOP; 51 mmHg). A ruptured anterior capsule with cortical lens matter and granulomatous reaction was seen in anterior chamber (AC) along with absorbed cataract. Treatment with antiglaucoma medications, steroids followed by AC wash, anterior capsulotomy with anterior vitrectomy normalized IOP and inflammation reduced. Lens particle glaucoma is a rare presentation of HSS. Therefore, early cataract surgery is recommended that also avoids the risk of suppression amblyopia.
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