The study purposed to evaluate the success rate of cervical ripening using dinoprostone controlled-release vaginal insert and reveal some factors relating to successful cervical ripening. Methods: This cross-sectional study was conducted at Tu Du Hospital in Vietnam from December 2021 to August 2022. The study enrolled 200 pregnant women with gestational age ≥37 weeks diagnosed with oligohydramnios. These candidates underwent dinoprostone cervical ripening (DCR) according to the local protocol. The Bishop score ≥7 after 24 h was determined for the successful cervical ripening (SCR). Results: In total, the success rate of DCR achieved at 57.5% and the cesarean delivery rate was 46.5%. None of the severe side-effects and complications was present. Using multivariable logistic regression, the study found that the body mass index ≥25 kg/m 2 and oxytocin infusion drip related to SCR with adjusted odds ratio (aOR): 3.67 (95% confidence intervals [CI]: 1.78-7.57) and aOR: 4.68 (95% CI: 1.84-11.93), p < 0.001. Using the Kaplan-Meier curve, the present study revealed a significant difference between Bishop <3 and ≥3 following the duration time of cervical ripening, with hazard ratio: 1.38 (95% CI: 1.19-1.59), p < 0.001. The time duration of cervical ripening was not significantly different following amniotic fluid index from 3 to 5 cm. Conclusions: Cervical ripening using a dinoprostone vaginal insert is a potentially acceptable method in term pregnancy accompanying with oligohydramnios. The probability of SCR can be predicted on a careful assessment of relative factors by obstetricians. Further studies are required to strengthen these findings.
Background: Oligohydramnios is one of the most common cause results in poor outcomes and induction of labor (IOL) remains an appropriately intervetional procedure for reducing the fetal mortality in term pregnancy. The primary purpose to evaluate the successful rate and materno-fetal adverse events by IOL using dinoprostone. The secondary purpose was to reveal some factors relating to successful IOL. Methods: This prospective study was conducted at T.D. Hospital from December 2021 to August 2022. The study enrolled 200 pregnant women of gestational age ≥ 37 weeks with oligohydramnios who underwent IOL by using dinoprostone. The Bishop score after 24 hours of IOL ≥ 7 is determined for evaluating the successful IOL. Results: The successful rate of IOL by dinoprostone was achieved at 57.5% and cesarean delivery rate was 46.5%. None of the severe side-effects and complications was present. Using multivariable logistic regression, the study found that BMI ≥ 25 kg/m2 and oxytocin augmentation related to success IOL with aOR: 3.67 (95% CI: 1.78-7.57) and aOR:4.68 (95% CI: 1.84-11.93), p < 0.001. Using the Kaplan-Meier curve, the present study revealed a significant difference between Bishop < 3 and ≥ 3 following the duration time of IOL, with HR: 1.38 (95% CI: 1.19-1.59), p < 0.001. The duration time of IOL was not significantly different following AFI from 3 to 5 cm. Conclusions: IOL by Dinoprostone is an acceptable procedure in term-pregnnacy accompanying with oligohydramnios. Predicting the success of IOL relating to some clinical factors can be evaluated by obstetricians.
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