With the rapid spread of the COVID-19 pandemic and the fact that most students of all grades in Vietnam were not fully vaccinated in 2021, the students had to study online for the first semester of the school year. Therefore, the students at all levels in general and the high school students particularly had a full experience of online learning. As a consequence, the research aims to investigate the experience of the high school students in e-learning in the case of Nguyen Trai High School in Ninh Thuan Province. The data was collected via online questionnaires toward the end of the first semester of the 2021-2022 academic year to find out the e-learning experience of the students at Nguyen Trai High School in Ninh Thuan Province. 174 participants responded the online questionnaires to be involved in the study. The findings of the study revealed that the majority of students had a favorable experience with e-learning. However, there have been some drawbacks needed to be considered for further development in e-learning education at high schools.