BACKGROUNDCoronary revascularization guided by fractional flow reserve (FFR) is associated with better patient outcomes after the procedure than revascularization guided by angiography alone. It is unknown whether the instantaneous wave-free ratio (iFR), an alternative measure that does not require the administration of adenosine, will offer benefits similar to those of FFR. METHODSWe randomly assigned 2492 patients with coronary artery disease, in a 1:1 ratio, to undergo either iFR-guided or FFR-guided coronary revascularization. The primary end point was the 1-year risk of major adverse cardiac events, which were a composite of death from any cause, nonfatal myocardial infarction, or unplanned revascularization. The trial was designed to show the noninferiority of iFR to FFR, with a margin of 3.4 percentage points for the difference in risk. RESULTSAt 1 year, the primary end point had occurred in 78 of 1148 patients (6.8%) in the iFR group and in 83 of 1182 patients (7.0%) in the FFR group (difference in risk, −0.2 percentage points; 95% confidence interval [CI], −2.3 to 1.8; P<0.001 for noninferiority; hazard ratio, 0.95; 95% CI, 0.68 to 1.33; P = 0.78). The risk of each component of the primary end point and of death from cardiovascular or noncardiovascular causes did not differ significantly between the groups. The number of patients who had adverse procedural symptoms and clinical signs was significantly lower in the iFR group than in the FFR group (39 patients [3.1%] vs. 385 patients [30.8%], P<0.001), and the median procedural time was significantly shorter (40.5 minutes vs. 45.0 minutes, P = 0.001). CONCLUSIONSCoronary revascularization guided by iFR was noninferior to revascularization guided by FFR with respect to the risk of major adverse cardiac events at 1 year. The rate of adverse procedural signs and symptoms was lower and the procedural time was shorter with iFR than with FFR. ( Use of Instantaneous Wave-free R atio in PCI F or the past 20 years, physiological measurements obtained during invasive procedures have been used to guide coronary revascularization. Pioneering work supported the use of flow measurements to make safe decisions about revascularization, 1,2 but this approach was soon superseded by the use of fractional flow reserve (FFR), which measures pressure as a surrogate of flow to estimate the severity of stenosis. 3-5 FFR was successful largely because of its technical simplicity and because clinical trials showed that it was associated with improved clinical outcomes after percutaneous coronary intervention (PCI). 6,7 Consequently, FFR is now included in the appropriate-use criteria for coronary angiography and in the American College of Cardiology-American Heart Association-European Society of Cardiology guidelines; despite these recommendations, its adoption remains limited. [8][9][10] FFR must be measured during maximal hyperemia, which is typically induced with the administration of a potent intravenous or intracoronary vasodilator, such as adenosine. 11 Several studies have...

No abstract

Overall, deferral of revascularization is equally safe with both iFR and FFR, with a low MACE rate of about 4%. Lesions were more frequently deferred when iFR was used to assess physiological significance. In deferred patients presenting with ACS, the event rate was significantly increased compared with SAP at 1 year.

In this large single-center experience with sutureless aortic valve replacement, the surgical procedure is shown to be safe and time-saving. In view of the excellent hemodynamic results and shortening of aortic crossclamp and bypass times, we notice advantages especially in high-risk patients. Minimally invasive access seems to be facilitated. The long-term durability of this prosthesis has yet to be determined.

Sirs:Coronary artery fistulas are anomalous connections between a coronary artery and a cardiac chamber or great vessel [1]. They are rare abnormalities with a reported incidence of 0.13-0.18% of patients undergoing coronary angiography [2,3]. The majority of coronary artery fistulas are congenital in origin, but they have been reported as acquired complications of chest trauma and surgery also. Most of them are diagnosed incidentally in asymptomatic patients, but depending on shunt volume, congestive heart failure can develop [1]. Furthermore, myocardial ischemia due to a 'steal' from the adjacent myocardium has been reported [4][5][6][7][8][9][10][11][12], but true existence of this phenomenon is a controversial issue [13]. We present the case of a young female with a large coronary artery fistula originating from the proximal left anterior descending artery (LAD), and evidence of a coronary steal syndrome is provided by fractional flow reserve (FFR).A so far healthy 36-year-old female without cardiovascular risk factors presented in our emergency department with sudden onset chest pain following a long exhausting motorbike trip. Physical examination was unremarkable, and no cardiac murmur was audible. Baseline electrocardiogram showed T inversions in the anterior leads, and the cardiac biomarkers were elevated with a peak high sensitive Troponin T of 0.55 lg/l and a peak creatine kinase of 623 U/l. Subsequent left heart catheterization ruled out coronary artery disease, but a large coronary artery fistula originating from the proximal LAD draining into to the pulmonary trunk was found (Fig. 1). Ventriculography showed a hypokinesis of the anterior segments distal to the origin of the fistula, and magnetic resonance tomography revealed a late enhancement pattern of subendocardial myocardial infarction (Fig. 2). Hypothesizing a coronary steal syndrome due to the fistula, a second procedure with left and right heart catheterization was performed. Hemodynamic and oximetric measurements revealed a systemic blood flow (Q S ) of 6.0 l/min and a pulmonary blood flow (Q P ) of 6.7 l/min, leading to a relatively small calculated left-to-right shunt of 0.68 l/min (Q P /Q S = 1.12), and pulmonary artery pressure was in normal range. FFR in the distal LAD was 0.78 under maximal hyperemia, raising to 0.95 while temporary experimental occlusion of the fistula using a 3.0/15 mm standard balloon catheter. In consideration of this evidence of steal syndrome, coil embolization of the fistula was performed in the same procedure, using 2 Detach TM embolization coils (Cook Medical, Bloomington, IN, USA) [2-2 and 2-4 (diameter in mm-length in cm)] in each of the two main branches and another two coils (3-4 and 3-6) in the bifurcation of the fistula (Fig. 1). Finally, a FFR of 1.0 was measured in the distal LAD. The patient was discharged free of symptoms the following day. At 3-month follow-up, the patient was free of symptoms, and echocardiography revealed complete recovery of left ventricular function.A coronary artery fistula is ...