The effects of replacement of sugarcane by spineless cactus (0, 33, 66, and 100 % on dry matter (DM) basis) were evaluated on intake, digestibility of nutrients, ingestive behavior, and performance of finishing lambs. Thirty-six non-castrated Santa Ines lambs at 4 months of age and an initial body weight of 22 ± 2.3 kg were assigned in a randomized block design. A quadratic effect was found for intake of DM, organic matter (OM), crude protein (CP), neutral detergent fiber (NDF), and digestible organic matter (DOM), with maximum values of 1.31, 1.19, 0.219, 0.358, and 0.845 g/day estimated with 42.5, 38.5, 38.8, 21.3, and 44.9 % replacement level, respectively. The digestibility of DM, OM, CP, and EE increased linearly; however, there was a quadratic effect on NDF digestibility with maximum value estimated of 500 g/kg with 64.2 % replacement level. Rumination time, total chewing, and rumination efficiency decreased linearly with the replacement levels; however, idle time increased linearly. A quadratic effect was found for final weight, body weight gain, and total weight gain with maximum values estimated of 38.6 kg, 0.232 kg/day, and 16.2 kg with 39.1, 38.2, and 40.4 % replacing levels. The replacement of 49.5 % sugarcane by spineless cactus can be recommended as optimal level, and problems related to intake, digestibility, and performance are concentrated outside that level.