Background: Diabetic retinopathy is one of the most common micro vascular complication of diabetes and involves an abnormal pathology of major retinal pigment epithelium, inter retinal oedema and intraocular neovascularisation where pro-inflammatory proteins including ICAM-1,iNOS and VEGF release by activation of enzyme CaMKII/NF-kB expression Diabetic induced oxidative stress followed by deactivation of Brn3a expression in the retinal ganglionic cells are also early events in pathogenesis of Diabetic retinopathy. These factors are important contributors to the development of clinically significant diabetic retinopathy. Objective: Objective of this study to examine the effect of curcumin with antioxidant and anti-inflammatory properties obtained from Curcuma longa against diabetes-induced retinal vascular damage and its mechanism of action by in-vivo in retinas of rat rendered diabetic by alloxan and in vitro in western blotting and RGC tissue culture. Method: We administered curcumin or saline vehicle to experimental animals daily for 12 weeks. Vascular permeability, expression of CaMK II/NF-kB, Retinal morphology and neuropathic change of the retinal ganglion cells were investigated. Results: As an anti-oxidant, curcumin raised Retinal Ganglionic cells by increasing Brn3a expression during oxidative stress condition and subsequently decreased the expression of inflammatory mediators such as VEGF, iNOS and ICAM-1 as an anti-inflammatory agent by inhibiting CaMKII and NF-kB expression. Conclusion: Curcumin, a common food additive has beneficial effects in experimental studies of diseases that are characterised by increased oxidative stress and inflammatory reactions. It appears to be a useful adjunct therapy to possibly inhibit the progression of retinopathy, sight threatening complication faced by diabetic patients.

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Objective: Plant-inferred bioactive particles have been utilized to turn away or treat tumor for a considerable length of time. As of late plant blends were found to have significantly more grounded exercises than utilizing plant alone. In this study, we evaluated the anticancer impacts of DPSUU III which contains a mix of plant concentrates of Beta vulgaris, Syzygium cumini, Limonia acidissima. Material and Methods: After extraction from these plants, DPSUU III was granulated and powder was extricated with 80% ethanol, dried by rotating evaporator under vacuum and put away until utilize. DPSUU III was offered orally to mice at single measurements of 1000mg/kg/day alongside vehicle control and creatures were seen amid the initial 12 hr for any change in side effects of mobility, posture, amount of sustenance utilization and for mortality after MCF-7 cells were infused into mammary cushion of C57BL6 mice to create strong breast tumours. Then DPSUU III treated gathering was contrasted with the doxorubicin (Dox)-treated gathering. Results: The breast disease development was altogether stifled in mice treated with DPSUU III without loss of body weight and any symptoms while Dox-treated mice showed huge body weight reduction with little measure of toxicities. An expansion in life expectancy (ILS% = 62.80%) was seen in the DPSUU III -controlled gathering, contrasted with the tumor control bunch. DPSUU III shows hostile to proliferative movement against MCF-7 breast tumor cells through actuating G0/G1 cell cycle capture. DPSUU III hinders the declaration of cyclin D1, CDK4, CDK2 and prompts p21. Conclusion: DPSUU III could be a potential chemo preventive supplement to breast tumor patients.