Data security is an infrastructure designed to protect and secure data from unauthorized access, data manipulation, malfunction, destruction, and inappropriate data disclosure. Currently, organizations widely use data transfer to validate and verify data using different media particularly in host-to-host connections. This research focuses on data exchanged (end-to-end communication) using Multi Protocol Label Switching (MPLS), metro ethernet, and Software Defined Wide Area Network (SD-WAN) network architecture with third parties. This research aims to develop a design and analysis framework for verifying data transferred from one host to another in ABC organization by applicable security standards that are appropriate and follow its needs to help the organization. Furthermore, the analysis result is used as materials for drafting a cybersecurity framework through the three standards ISO/EIC 27001:2013, NIST SP800-161, and ITU-T X.805. The methodology used in this study is the comparative analysis of three frameworks, requirement analysis, and content analysis to develop a framework. The framework proposed of eight security dimensions, five threats, and providing mitigation is expected to enhance the security system of data exchange on host-to-host connections in ABC organization.