Introduction: Aneurysmal bone cyst is a rare, non-neoplastic lesion affecting the metaphysis of long bones and vertebrae, characterized by blood-filled spaces separated by fibrous septae.
Aims and objectives: In this study, we present a case of an aneurysmal bone cyst in a 7-year-old child with characteristic X-ray findings to increase awareness as early diagnosis and treatment can limit disability.
An aneurysmal bone cyst is a rare, benign neoplastic lesion affecting the metaphysis of long bones and vertebrae, characterized by blood-filled spaces separated by fibrous septae.[1] Diagnosis depends on typical features of magnetic resonance imaging, and confirmation by biopsy is essential before surgery is considered.
We present an aneurysmal bone cyst in a 7-year-old child with characteristic X-ray findings. Diagnosis of ABC should be suspected in young patients presenting with limb pain or swelling, and pain disproportionate to the mechanism of injury could indicate pathologic fracture. Early detection of ABC is possible as an incidental finding by closely examining routine X-rays so that appropriate treatment can be instituted early and complications like pathologic fractures can be avoided. This case will help to increase awareness as early diagnosis and treatment can limit disability.
Enchondromas are intramedullary cartilage neoplasms with benign imaging features that constitute approx. 90% of benign tumours in the hands.
We present a 25-year-old previously fit and well female patient with Enchondroma of the metacarpal bone with characteristic imaging and pathologic fracture to increase its awareness for early diagnosis and treatment.
Context:
Haematological toxicities are seen in rectal cancer patients receiving concurrent chemoradiotherapy (CRT) with capecitabine.
Aims:
To compare dose volume histogram (DVH) parameters and acute haematological toxicities using RapidArc with or without bone marrow constraints for rectal cancer patients receiving pelvic chemoradiation as part of curative treatment.
Setting and designs:
This is a prospective randomised controlled study including patients with rectal cancer initiated on chemoradiation. Patients were stratified into two arms, bone marrow sparing (BMS) arm and non-bone marrow sparing arm (NBMS).
Materials and methods:
DVH parameters and weekly toxicity data were collected. Grade 2 or more anaemia, leucopenia, neutropenia, or thrombocytopenia, any blood transfusions, colony-stimulating factor injection, platelet transfusions were considered as an event in acute haematological toxicity (HT).
Statistical analysis:
Independent t-test was used to compare quantitative parameters, and Mann–Whitney U-test was used for ordinal parameters between groups.
Results:
A total of 43 patients were enrolled. Bone marrow constraints were achieved without compromising the target coverage. There was a significant reduction in the bone marrow dose with BMS technique (p < 0·05). A 16·7% reduction in the HT (33·3% versus 50%) and a 21·9% reduction in the grade 2 or more anaemia (19% versus 40·9%) were noted in the BMS arm when compared to NBMS arm, though not statistically significant. However, in the preoperative setting, a significant reduction in grade 2/more anaemia (7·1% versus 41·1%, p = 0·035) was noticed in the BMS arm.
Conclusions:
Pelvic BMS radiotherapy may benefit patients receiving chemoradiation for locally advanced carcinoma rectum as part of curative treatment.
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