No abstract

We consider several types of internal queries: questions about subwords of a text. As the main tool we develop an optimal data structure for the problem called here internal pattern matching. This data structure provides constanttime answers to queries about occurrences of one subword x in another subword y of a given text, assuming that |y| = O(|x|), which allows for a constant-space representation of all occurrences. This problem can be viewed as a natural extension of the well-studied pattern matching problem. The data structure has linear size and admits a linear-time construction algorithm.Using the solution to the internal pattern matching problem, we obtain very efficient data structures answering queries about: primitivity of subwords, periods of subwords, general substring compression, and cyclic equivalence of two subwords. All these results improve upon the best previously known counterparts. The linear construction time of our data structure also allows to improve the algorithm for finding δ-subrepetitions in a text (a more general version of maximal repetitions, also called runs). For any fixed δ we obtain the first linear-time algorithm, which matches the linear time complexity of the algorithm computing runs. Our data structure has already been used as a part of the efficient solutions for subword suffix rank & selection, as well as substring compression using Burrows-Wheeler transform composed with run-length encoding.The model of internal queries in texts is connected to the well-studied problem of text indexing. Both models have their origins in the introduction of suffix trees. However, there is an important difference: in our model the size of the representation of a query is constant and therefore enables faster query time. Our results can be viewed as efficient solutions to "internal" equivalents of several basic problems of regular pattern matching and make an improvement in a majority of already published results related to internal queries.

The RNA Bricks database (http://iimcb.genesilico.pl/rnabricks), stores information about recurrent RNA 3D motifs and their interactions, found in experimentally determined RNA structures and in RNA–protein complexes. In contrast to other similar tools (RNA 3D Motif Atlas, RNA Frabase, Rloom) RNA motifs, i.e. ‘RNA bricks’ are presented in the molecular environment, in which they were determined, including RNA, protein, metal ions, water molecules and ligands. All nucleotide residues in RNA bricks are annotated with structural quality scores that describe real-space correlation coefficients with the electron density data (if available), backbone geometry and possible steric conflicts, which can be used to identify poorly modeled residues. The database is also equipped with an algorithm for 3D motif search and comparison. The algorithm compares spatial positions of backbone atoms of the user-provided query structure and of stored RNA motifs, without relying on sequence or secondary structure information. This enables the identification of local structural similarities among evolutionarily related and unrelated RNA molecules. Besides, the search utility enables searching ‘RNA bricks’ according to sequence similarity, and makes it possible to identify motifs with modified ribonucleotide residues at specific positions.