ProBiS-Database is a searchable repository of precalculated
local
structural alignments in proteins detected by the ProBiS algorithm
in the Protein Data Bank. Identification of functionally important
binding regions of the protein is facilitated by structural similarity
scores mapped to the query protein structure. PDB structures that
have been aligned with a query protein may be rapidly retrieved from
the ProBiS-Database, which is thus able to generate hypotheses concerning
the roles of uncharacterized proteins. Presented with uncharacterized
protein structure, ProBiS-Database can discern relationships between
such a query protein and other better known proteins in the PDB. Fast
access and a user-friendly graphical interface promote easy exploration
of this database of over 420 million local structural alignments.
The ProBiS-Database is updated weekly and is freely available online
at .
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