No abstract

No abstract

Summary The actions of noradrenaline (NA) on the smooth muscle of the guinea-pig vas deferens in tetraethylammonium (TEA) medium have been studied under constant-current and voltage-clamp conditions. The marked changes observed during exposure to NA are 1) slowness in the rising phase of the action potential, delay in the falling phase and reduction in the amplitude, and 2) depression of the voltage-dependent Cat + current with a negative shift of its reversal potential as well as with a reduction in its conductance. These findings might suggest that NA application stimulates the voltage-independent Cat + machinery, but suppresses the voltage-dependent Cat + machinery through membrane.

No abstract

The effects of ƒÀ-adrenoceptor stimulation by isoprenaline (ISO)