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Even purely aliphatic aldehydes, as well as aromatic aldehydes, were alkylated enantioselectively with dialkylzinc reagents in high enantiomeric excess using (1) as a chiral catalyst.Generally, enantioselective addition of organometallic reagents to aliphatic aldehydes is less enantioselective than addition to aromatic aldehydes,l probably owing to the stereoelectronic effect of the aryl groups.2There have been some recent reports on the enantioselective addition of dialkylzinc reagents to aldehydes using chiral catalysts.3 However, the maximum enantiomeric excess (e.e.
Highly enantioselective conjugate addition of dialkylzinc reagents to aryl substituted enones using Ni(ii)-bipyridyl-chiral ligand in acetonitrile (MeCN)/toluene as an in situ prepared catalyst system affords P-substituted ketones in up to 90% enantiomeric excess (e.e.).
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