A female spayed domestic shorthair with an estimated age of 8 to 10 years was presented with chief complaints of cervical ventroflexion, seizure, and collapse. Blood examination revealed hypokalemia, and abdominal radiography and ultrasound examination showed a mass cranial to the right kidney, possibly originating from the right adrenal gland. Medical treatment for hypokalemia resulted in minimal improvement of the clinical signs. Additional examination revealed a high aldosterone level and low serum renin activity. The mass was removed and histopathologically diagnosed as an adrenal adenocarcinoma. Based on these results, the cat was diagnosed with primary aldosteronism secondary to an adrenal adenocarcinoma. The cat exhibited rapid postsurgical improvement in the clinical signs and hypokalemia. The cat survived for an additional 4 years 5 months.

Summary:A 12-year-old neutered male miniature dachshund was presented with intermittent ataxia. Solitary osseous plasmacytoma (SOP) in the 12th thoracic vertebra (T12) was diagnosed based on the results of diagnostic imaging and histopathology. The combination use of zoledronic acid, melphalan, and prednisolone was extremely effective and long term survival could be achieved, however, mandibular osteonecrosis developed as a suspected adverse effect of zoledronic acid 2 years later. This is the first clinical report of an adverse effect of zoledronic acid in a dog with SOP.

Summary: a 13-year-old female Welsh Corgi was treated for refractory glaucoma. Ultrasound examination suggested an intraocular tumor. Computer tomography (CT) revealed hyperattenuating lesions in the affected eye. enucleation was performed and intraocular osteosarcoma was diagnosed by histopathology. The tumor recurred at the surgical area on the 46th day after surgery. intracranial tumor invasion was suspected based on clinical signs, and the dog was euthanized. Based on this case, CT scanning may be useful for detecting primary intraocular osteosarcoma. These tumors may show malignant behavior and severe local invasiveness compared with other types of intraocular tumors.