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Aging is associated with decreased skeletal muscle function. Increased levels of advanced glycation end products (AGEs) in skeletal muscle tissue are observed with advancing age and in diabetes. Although serum AGE level is negatively associated with grip strength in elderly people, it is unknown whether this association is present in adult males. To determine the relationship between AGE accumulation in tissue and muscle strength and power among Japanese adult men. Skin autofluorescence (AF) (a noninvasive method for measuring tissue AGEs), grip strength (n = 232), and leg extension power (n = 138) were measured in Japanese adult men [median (interquartile range) age, 46.0 (37.0, 56.0) years]. After adjustment for potential confounders, the adjusted means [95% confidence interval (CI)] for grip strength across the tertiles of skin AF were 44.5 (43.2, 45.9) kg for the lowest tertile, 42.0 (40.6, 43.3) kg for the middle tertile, and 41.7 (40.3, 43.1) kg for the highest tertile (P for trend < 0.01). Moreover, the adjusted geometric means (95% CI) of leg extension power across the tertiles of skin AF were 17.8 (16.6, 19.1) W/kg for the lowest tertile, 17.5 (16.4, 18.7) W/kg for the middle tertile, and 16.0 (14.9, 17.1) W/kg for the highest tertile (P for trend = 0.04). Among Japanese adult men, participants with higher skin AF had lower muscle strength and power, indicating a relationship between AGE accumulation and muscle strength and power. A long-term prospective study is required to clarify the causality.

In order to elucidate how the oxide-ion electron mixed conduction in an oxide cathode affects the kinetics of the cathode reaction in solid oxide fuel cells, a compact La0 63Sr0 27MnO, layer was prepared as a working electrode on the electrolyte of 3 mole percent Y203 doped Zr02 by a laser flash evaporation method, and electrochemical measurements were made as a function of oxygen partial pressures, P(02), at 700 to 900°C. Contrary to the case of a porous electrode system, the electrode interface conductivity was found to increase with decreasing P(02). With large anodic polarization, the oxide layer was found to be peeled off by oxygen evolution at the electrode/stabilized zirconia interface. The kinetics controlled by chemical diffusion of oxygen in the oxide layer were observed under cathodic polarization with P(O,) < i0Pa at 900°C.The oxide ion conductivity in La,nSro27MnO3 was found to be proportional to where a0 is the oxygen activity in the oxide.) unless CC License in place (see abstract). ecsdl.org/site/terms_use address. Redistribution subject to ECS terms of use (see 141.211.4.224 Downloaded on 2015-06-20 to IP

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