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Little is known on how different types of disasters interact in their impacts on patient care. We experienced a breast cancer patient whose initial presentation was delayed for 2 years due to the COVID‐19 pandemic and Typhoon Hagibis. Increasing awareness is needed on the combined impacts of disasters on breast cancer management.

Accurate and timely follow-up is essential for breast cancer patients throughout their course of treatment. However, the novel coronavirus disease 2019 (COVID-19) pandemic has readily hampered the continuation of breast cancer care in many parts of the world and Japan is no exception. In Japan, one of the first cases of COVID-19 was detected in March 2020 in Tokyo, and from April to May 2020, the Japanese government declared a state of emergency in Tokyo and some other prefectures as the daily number of COVID-19 cases increased exponentially. Consequently,

No abstract

In order to determine the effect of immunosuppressive acidic protein (TAP) on the formation of pancreatic carcinoma, rats of the Sprague-Dawley strain were embedded with 7,12-dimethylbenzanthracene (DMBA) in the pancreas with and without administration of TAP. In these animals, the growth of pancreatic cancer was studied both immunologically and histologically. Tumor was induced in 51 animals (85%) of 60 treated with embedding of 1 mg DMBA alone. Tumors began to appear from the 16th week after the embedding. Among animals in which tumor was induced, tubular adenocarcinoma and pleomorphic carcinoma accounted for 55% of the cases. When administration of TAP was combined, the period required for development of tumor was shortened. It became shorter with increases in the dosage and frequency of administration of TAP. In animals which received TAP in a mean dose of 75 mg/kg the area showing cancerous changes appeared as early as at the 8th week after the embedding of DMBA. A significant increase in the volume of tumors was seen in the group treated with TAP as compared to the group not treated with TAP. Animals which received TAP in increasing doses and frequencies showed an accelecrated increase in the volume of the tumors which underwent cancerous changes. TAP was eliminated from the serum of rats within 72 hr after the administration, and acid protein was clearly recovered from the serum when tumors proliferated. These findings indicate that the acceleration of carcinogenesis in DMBA-induced pancreatic carcinoma may be attributable to the immunosuppressive effect of TAP administered and tend to be dependent on the dosage and frequency of its administration in the early phase of tumor induction.experimental pancreatic cancer ; 7,12-dimethyl benzanthracene ; immunosuppressive acidic proteinAs an approach to the diagnosis and treatment of pancreatic carcinoma, establishment of experimental models of pancreatic carcinoma has been attemped (Druckrey et al. 1968;Pour et al. 1975). Heretofore, few papers have been published describing the preparation of experimental models of pancreatic car-