Limited venous access in neonates often leads to the need to coadminister intravenous drugs and/or parenteral nutrition via the same catheter. 1 Most neonates only tolerate the insertion of a single or double lumen central venous catheter or peripherally inserted central catheter. 2 Co-administration increases the risk of incompatibility reactions between the infused solutions because of differences in their physicochemical properties. 3 Consequences of incompatibilities may result in precipitation of solid particles or increase in oil-droplet size for emulsions. This can lead to lumen occlusion, embolus formation and organ malfunction. [4][5][6] Two retrospective studies