No abstract

The long non-coding RNA, urothelial cancer-associated 1 (UCA1) is an important regulator in several tumors. However, to the best of our knowledge, the clinical roles of UCA1 in cervical cancer remain unclear. Thus, the present study aimed to investigate the function and mechanism of UCA1 in cervical cancer. Reverse transcription-quantitative PCR analysis was performed to detect UCA1 and microRNA (miR)-299-3p expression in cervical cancer tissues and cell lines. The Cell Counting Kit-8 and Transwell assays were performed to assess cell proliferation and invasion, respectively. Furthermore, the dual-luciferase reporter assay was performed to confirm the association between UCA1 and miR-299-3p. Rescue experiments were performed to determine the mechanism of the UCA1/miR-299-3p axis. The results demonstrated that UCA1 expression was upregulated in cervical cancer tissues and cell lines. Furthermore, overexpression of UCA1 enhanced the proliferation and invasion of cervical cancer cells, the effects of which were reversed following UCA1 knockdown. Notably, UCA1 interacted with miR-299-3p and negatively regulated miR-299-3p expression. In addition, miR-299-3p expression was downregulated in cervical cancer tissues and cell lines. Overexpression of miR-299-3p suppressed the proliferation and invasion of cervical cancer cells, reversing the effects of UCA1 knockdown on cervical cancer cell proliferation. Taken together, the results of the present study suggest that UCA1 promotes cell proliferation and invasion by regulating miR-299-3p expression in cervical cancer.

No abstract

The long-afterglow phosphor SrAl 2 O 4 : Eu 21 , Dy 31 is liable to hydrolyze in water with deterioration of its luminescent properties. In this study, in situ emulsion polymerization was first used to prepare phosphor coated with poly(methyl methacrylate-co-butyl acrylate) [P(MMA-co-BA)] to improve water resistance. Fourier transform infrared spectra suggested that the polymer attached to the phosphor by chemical bonding. Observation by scanning electron microscopy (SEM) showed that a polymer layer formed on the surface of the phosphor. The resistance to water of the phosphor coated with the polymer layer was much better than that of the uncoated phosphor because the transparent polymer layer could suppress its hydrolysis process. Low-density polyethylene (LDPE) plastics, doped with long-afterglow phosphors, were manufactured with an extrusion technique. Through coating with P(MMA-co-BA), the compatibility of phosphor with the LDPE matrix was improved, as determined by SEM. The luminous LDPE plastics blended with the phosphor coated with polymer showed long and strong phosphorescence with little loss of persistence phosphorescence compared to the uncoated phosphor. The LDPE plastics still retained their mechanical properties through doping with 3% (mass fraction) of the phosphors.

was first grafted with poly(butyl acrylate)-poly(methyl methacrylate) (core-shell) (designed as PMMA(PBA)) by in situ emulsion polymerization. The properties of polymer/ phosphor composite particles were characterized by fourier transform infrared, X-ray photoelectron spectroscopy, and thermogravimetric analysis. The results show that the polymer had grafted onto the phosphor by chemical bond and the grating ratio was about 6.3%. The results for PVC plastics characterized by scanning electron microscopy show that the interfacial adhesion was enhanced with filling the polymer/phosphor composite particles and the compatibility of phosphor with PVC matrix was improved by coating with PMMA(PBA). And the luminescent PVC plastics filled with PMMA(PBA)/phosphor composite particles show improved mechanical properties and higher phosphorescence when the filling content was more than 3 phr compared with the unmodified phosphor.