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NeuRobot, a micromanipulator system with a rigid neuroendoscope and three micromanipulators, was developed for less invasive and telecontrolled neurosurgery.This system can be used to perform sophisticated surgical procedures through a small window 10 mm in diameter. The present study was performed to evaluate the feasibility of using NeuRobot in neuroendoscopy. Four different intraventricular neurosurgical procedures were performed using NeuRobot in three fixed cadaver heads: 1) fenestration of the floor of the third ventricle, 2) fenestration of the septum pellucidum, 3) biopsy of the thalamus, and 4) biopsy of the choroid plexus of the lateral ventricle.Each procedure required less than 2 min, and all procedures were performed accurately.After these surgical simulations using cadaver heads, third ventriculostomy was carried out safely and adequately in a patient with obstructive hydrocephalus due to a midbrain venous angioma. Our results confirmed that NeuRobot is applicable to lesions in which conventional endoscopic neurosurgery is indicated. Furthermore, NeuRobot can perform more complex surgical procedures than a conventional neuroendoscope because of its maneuverability and stability. NeuRobot will become a useful *Manuscript H. Takasuna, et al.-2 -neurosurgical tool for dealing with lesions that are difficult to treat by conventional neuroendoscopic surgery.