This paper presents a comparative performance analysis of wireless orthogonal frequency division multiplexing (OFDM) system with the implementation of comb type pilot-based channel estimation algorithm over frequency selective multi-path fading channels. The Minimum Mean Square Error (MMSE) method is used for the estimation of channel at pilot frequencies. For the estimation of channel at data frequencies different interpolation techniques such as low-pass, linear, and second order interpolation are employed. The OFDM system simulation has been carried out with Matlab and the performance is analyzed in terms of bit error rate (BER) for various signal mapping (BPSK, QPSK, 4QAM, 16QAM, and 64QAM) and channel (Rayleigh and Rician) conditions. The impact of selecting number of channel taps on the BER performance is also investigated.