The intraperitoneal (IP) administration of antineoplastic agents has been proposed as a method to improve the efficacy of therapy of malignant disease principally confined to the peritoneal cavity especially in carcinoma-ovary. Our patient who had more tumor burden in the peritoneum was refractory to two lines intravenous (IV) chemotherapy who improved on IP administration of platinum and IV nab paclitaxel chemotherapy regime. A 42-year-old lady was diagnosed with stage IV metastatic epithelial ovarian cancer. She suffered from progressive disease on two lines of IV chemotherapy following surgery with persistent rise in serum CA 125 level. Administration of IP platinum and IV nab paclitaxel chemotherapy regime resulted in complete (metabolic/radiological) response with normal CA 125 level. Intraperitoneal chemotherapy can be considered in patients with ovarian cancer with predominantly peritoneal disease.