A highly efficient and simple protocol for the synthesis of isothiocyanates and cyanamides from their respective amines in the presence of a mild, efficient, and non-toxic reagent tetrapropylammonium tribromide is described. High environmental acceptability of the reagents, cost effectiveness and high yields are the important attributes of this methodology.
A series of 1,3‐oxazine derivatives were synthesized by a one‐pot three‐component (ie, phenol, formaldehyde, amine) method where SiO2 bonded with NaCl was used as a reusable, more efficient, easily prepared, and available solid catalyst. The reactions were also carried out at room temperature for greener approach. in vitro studies for the synthesized compounds were also done against two gram‐positive (Bacillus subtilis and Staphylococcus aureus) and two gram‐negative bacteria (Escherichia coli and Klebsiella pneumonia) to check for their applicability as an antibacterial agent where some of the synthesized compounds gives the best antibacterial activity against selected bacterial strains. Streptomycin was used as a standard control for all the microbial test.
A study on the fruit of Parkia roxburghii and Rhus semialata, specifically found in Nagaland, is being done in this work which includes its phytochemical screening, trace element determination, anti-bacterial and antioxidant studies. Acetone and Ethanol were used for the extraction purpose. Furthermore, in vitro antioxidant studies for determining its free radical scavenging activity were carried out through the DPPH (2,2-diphenyl-1-picrylhydrazyl) and FRAP (ferric reducing antioxidant power) assay as compared with the reference standards Trolox and Ascorbic acid. The extracts were also evaluated for their anti-bacterial activity against four strains of bacteria and to further quantify the anti-bacterial studies, the MIC (Minimum Inhibitory Concentration) of both the samples were carried out by means of two-fold serial broth dilution method.
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