Enterotoxins produced by Clostridium difficile cause a series of biochemical and immunological manifestations in the cascade leading to alteration of the enterocitus cytoskeleton, intestinal inflammation and diarrhea that can greatly impair the patient's biological status. The genome of the Clostridium difficile bacterium shows a series of evolutionary adaptations that can give it a high degree of resistance or adaptability to many known pharmacological classes. Changing the diversity of intestinal microbiota induced by the use of antibiotics creates a favorable environment from all points of view for Clostridium difficile spore activity. The theme addresses in an original way but related to the epidemiological studies presented in the literature a correlative aspect between the pathological group and the infection with Clostridium difficile. From the data presented, there is a direct correlation between Clostridium difficile infection and the use of antibiotic therapy as a curative or preventive treatment. Gastrointestinal and neurological pathologies, due to the use of curative but also preventive antibiotic therapy, are at increased risk for the installation of Clostridium difficile infection. The study presented may be a first step in raising awareness of the rational use of antibiotics and avoiding non-assisted community antibiotic therapy.

Clostridium difficile is a microorganism - a Gram-positive anaerobic bacterium that has developed and hyperspecialized the ability to form spores. Outside the host, Clostridium difficile germinates spores which are resistant to unfavorable environment and for an extremely long time period. Clostridium difficile infection frequently occurs on a background of major disturbances in the balance of the normal intestinal flora caused by use for therapeutic purposes of broad-spectrum antibiotics. Patients infected with Clostridium difficile in medical facilities are usually elderly people, immunosuppressed or subjected to an antibiotic medication regimen. Wide-scale community use of antibiotics and proton-pump inhibitors induces favorable conditions for the germination of Clostridium difficile spores in the gastrointestinal tract.Clostridium difficile biocolonizes many domestic and wild animals. Clostridium difficile is a complex bacterium, capable of developing resistance forms that parasitize the gastrointestinal tract of humans, and also many animals. An important source of the Clostridium difficile infection is represented primarily by antibiotic medication administered in communities without medical recommendation, as well as food.