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The purpose of this study is to look into the influence of capital structure on the profitability of seventeen listed banks in Vietnam from 2012 to 2020. Return on Total Assets (ROA) is used to determine profitability, whereas Debt to Total Assets (DA), business size, growth potential, and tangibility are used to determine capital structure. Descriptive statistics, correlation, and panel data regression models were used to examine the data. The findings reveal that capital structure has a significant negative influence on a firm's profitability. Based on empirical research, these results provide important insights for banks and lending organizations.