Erwinia amylovora is the causal agent of fire blight, a devastating disease affecting some plants of the Rosaceae family. We isolated bacteriophages from samples collected from infected apple and pear trees along the Wasatch Front in Utah. We announce 19 high-quality complete genome sequences of E. amylovora bacteriophages.
We present here the complete genomes of 18 phages that infect Paenibacillus larvae, the causative agent of American foulbrood in honeybees. The phages were isolated between 2014 and 2016 as part of an undergraduate phage discovery course at Brigham Young University.
Passive leg movement (
PLM
)‐induced hyperemia is used to assess the function of the vascular endothelium. This study sought to determine the impact of movement speed and range of motion (
ROM
) on the hyperemic response to
PLM
and determine if the currently recommended protocol of moving the leg through a 90°
ROM
at 180°/sec provides a peak hyperemic response to
PLM
. 11 healthy adults underwent multiple bouts of
PLM
, in which either movement speed (60–240°/sec) or
ROM
(30–120° knee flexion) were varied. Femoral artery blood flow (Doppler Ultrasound) and mean arterial pressure (
MAP
; photoplethysmography) were measured throughout. Movement speed generally exhibited positive linear relationships with the hyperemic response to
PLM
, eliciting ~15–20% increase in hyperemia and conductance for each 30°/sec increase in speed (
P
< 0.05). However, increasing the movement speed above 180°/sec was physically difficult and seemingly impractical to implement.
ROM
exhibited curvilinear relationships (
P
<0.05) with hyperemia and conductance, which peaked at 90°, such that a 30° increase or decrease in
ROM
from 90° resulted in a 10–40% attenuation (
P
< 0.05) in the hyperemic response. Alterations in the balance of antegrade and retrograde flow appear to play a role in this attenuation. Movement speed and
ROM
have a profound impact on
PLM
‐induced hyperemia. When using
PLM
to assess vascular endothelial function, it is recommended to perform the test at the traditional 180°/sec with 90°
ROM
, which offers a near peak hyperemic response, while maintaining test feasibility.
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