Background: Tiopronin is a small molecule that selectively kills multidrug-resistant cancer cells. Results: Inhibition of glutathione peroxidase by tiopronin leads to elevated reactive oxygen species in MDR cells.
Conclusion: Tiopronin mediates the killing of MDR cells by inhibition of glutathione peroxidases.Significance: Glutathione peroxidase inhibition may be a viable strategy for modulation of multidrug resistance in cancer.
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