Thirteen human subjects scheduled for elective anterior segment eye surgery received hourly 2% voriconazole eye drops 4 hours presurgery. No side effects were reported. Significantly, the voriconazole concentration in the aqueous humor of the eye was similar to that reported for the 1% voriconazole solution, suggestive of concentration-independent absorption.

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Retinal pigment epithelial tears are most commonly found in the context of aged related macular degeneration with associated choroidal neovascular membrane or retinal pigment epithelial atrophy. We report a case of spontaneous giant pigment epithelial tear in a patient with only relevant history of head trauma many years prior to presentation.

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