Objectives Autologous CD133+ bone marrow stem cells may improve cardiac function. This randomized, single‐blind clinical trial inquired whether a combined transepicardial and transseptal implantation of CD133+ stem cells during coronary artery bypass grafting (CABG) improve cardiac function with ejection fraction (EF) changes as a primary endpoint in patients with low EF. Methods Thirty patients with coronary heart disease and EF <35% were randomized to undergo CABG alone or CABG with transseptal and transepicardial implantation of CD133+. Cardiac function was evaluated using cardiac magnetic resonance imaging (MRI) before and 6 months after CABG. Results Preoperative EF was lower in the intervention group (25.88% ± 5.66%) than in the control group (30.18% ± 3.85%; P = .04). The adverse event incidence was similar between both groups. At 6 months, EF changes were significantly higher (8.69% ± 9.49; P = .04) in the CD133+ group than in the CABG‐only group. Compared to the control group, significant improvements were seen in the wall motion score index (P = .003) and scar size proportion (P = .047) in the CD133+ group. The quality of life (QOL), assessed by a 6‐minute walking test, showed considerable improvement in the CD133+ group compared to that in the control group (P = .03). The Minnesota Living with Heart Failure Questionnaire (MLHFQ) scale did not show improvement in the intervention group (P = .09, vs control). Conclusion Combined transepicardial and transseptal autologous CD133+ BMC implantation during bypass grafting improved cardiac function in low EF coronary artery disease patients.
The means of designing an effective user interface software package varies from one application to another. Almost the entire ICT infrastructure was damaged following the impact of the tsunami tidal wave. Under such circumstances, transporting critically ill patients is a must and becomes the first priority. Many considerations are needed when designing a specific user interface for emergency situations in developing countries. In this study we proposed how to design the user interface in order to support emergency medical care in the early stages of disasters. The user interface was classified into two tabs, firstly to indicate critically ill patients and secondly to notify details of the medicine having been administered to the patients. Classifying the user interface of emergency medical care information systems by using VHF radio connections will be beneficial, especially for the early stages of disaster-stricken developing countries, in order to preserve the lives of more victims.
ABSTRAKAngka kematian kelompok rentan akibat bencana masih sangat tinggi, seperti kejadian banjir bandang Garut dari 34 orang korban jiwa 35,4% diantaranya berusia 55-80 tahun dan 29% merupakan anakanak usia 0-14 tahun. Upaya pengurangan resiko harus dilakukan dengan memberdayakan masyarakat sehingga proses penanggulangan lebih efektif dengan respon yang cepat. Usia remaja merupakan kelompok yang sangat potensial karena memiliki angka resiliensi yang sangat baik. Selain itu pertumbuhan jumlah remaja sangat pesat dari kelompok umur lainnya, sehingga pemberdayaan kelompok remaja dengan perencanaan kontinjensi diharapkan meningkatkan kesiapsiagaan terhadap ancaman kematian sehingga dapat melakukan pendampingan terhadap kelompok rentan. Penelitian ini bertujuan mengetahui pengaruh pemberdayaan (empowering) kelompok remaja akhir melalui pendekatan perencanaan kontinjensi dalam meningkatkan kesiapsiagaan remaja terhadap ancaman kematian akibat bencana. Penelitian menggunakan metoda quasi-experimental design dengan pendekatan rancangan one group pre-post test design. Populasi penelitian merupakan pelajar SMK diwilayah yang memiliki ancaman bencana. Jumlah sampel sebanyak 33 responden dengan teknik proporsional random sampling diambil dari empat sekolah yang berada di zona merah. Data diolah menggunakan analisis univariat menggunakan tendensi sentral, t-test dependent dengan tingkat kepercayaan 95% untuk melihat pengaruh dari intervensi, serta uji regresi linier ganda untuk menganalisis faktor mana yang paling berpengaruh terhadap kesiapsiagaan.Terdapat pengaruh pemberdayaan melalui pendekatan perencanaan kontinjensi dapat meningkatkan upaya kesiapsiagaan dengan nilai α (0.000). Peningkatan rerata (36,67%) didapatkan pada faktor yang mengawali kesiapsiagaan, diantaranya dilihat dari persepsi terhadap resiko, kewaspadaan terhadap ancaman, serta penurunan kecemasan. Faktor tersebut menstimulasi terbentuknya niat melakukan kesiapsiagaan dengan peningkatan (43,33%), bahkan meningkatkan upaya perencanaan kesiapsiagaan bencana sebesar (42,00%) sebelum dan setelah intervensi. Ketiga faktor tersebut saling berkaitan dan faktor pembentukan niat melakukan kesiapsiagaan menjadi faktor yang sangat berpengaruh terhadap kesiapsiagaan dengan nilai β (0,531). Hasil penelitian menunjukkan bahwa proses pemberdayaan melalui pendekatan perencanaan kontinjensi mampu meningkatkan kesiapsiagaan remaja terhadap ancaman kematian akibat bencana, sehingga dapat direkomendasikan bagi seluruh penggiat kebencanaan untuk memberdayakan remaja dengan perencanaan kontinjensi dalam upaya meningkatkan kesiapsiagaan terhadap ancaman kematian.
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