Hợp chất lai của 2-aminobenzothiazole có chứa nhóm 2-aminobenzamide qua cầu nối amide đã được thiết kế, tổng hợp thành công và cấu trúc được xác định bằng các phương pháp phổ cộng hưởng từ hạt nhân (NMR), phổ khối lượng phân giải cao (HRMS). Hợp chất (3) tổng hợp cũng đã được thử hoạt tính kháng tế bào ung thư người in vitro trên hai dòng tế bào A549 và SW480. Kết quả thu được cho thấy, hợp chất (3) không thể hiện hoạt tính đối với dòng tế bào SW480 nhưng lại thể hiện độc tính đối với dòng tế bào A549 với giá trị IC50 là 29.49 µM.

Twelve new compounds including 2-aminobenzamide derivatives bearing benzothiazole and phenylamine moiety were designed and synthesized. The synthesized compounds were tested their cytotoxic activity against A549 and SW480 tumor cell lines. Compounds 3a and 3c exhibited cytotoxicity toward A549 cell line with IC50 values of 24.59 and 29.59 µM, respectively.

This study was conducted to determine organophosphate ester compounds in indoor dust in Hanoi ‐ a populated city in Vietnam. In the study, the concentration and distribution of fifteen organophosphate esters (OPEs) were analyzed in indoor dust specimen. In general, the recorded total concentrations of OPEs in dust ranged from 2.7 to 14.1 μg/g and the average quantities varied from 0.2 to 1.0 μg/g. Particular, 100 % of survey samples were detected signals of OPEs, indeed, tris‐(2‐chloroisopropyl) phosphate (TCPP) and tris(2‐butoxyethyl)phosphate (TBEP) were two of the OPE substances, which their content accounted for the most in 15 analyzed compounds. OPE emission sources in indoor dust could be from locally used wide variety of consumer products and building materials in Hanoi houses. Moreover, tri‐m‐cresyl phosphate (TMCP) was practically observed in survey dust samples, and thus effects of traffic activities on OPEs contamination were not significant. Estimating human exposure to OPEs through directly absorbing foods was implemented and illustrated that this absorption route did not substantially affected adult and children health.