Rheumatoid arthritis is an autoimmune disease that can cause chronic inflammation of the joints and may involve other areas of the body. Rheumatoid arthritis can cause permanent joint destruction and deformity. Rheumatoid factor is an antibody that can be found in the blood of 80% of people with rheumatoid arthritis. ESR and C reactive protein are the marker of inflammation. A case report of a 38-years-female, having multiple joint pain in both hands was treated successfully with the Ayurvedic treatment, has been presented here.