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In this study, we demonstrate a simple approach to fabricate a high-performance random laser from the natural inverse photonic glass structure of Artemia eggshells. Herein, the three-dimensional structures of Artemia eggshells provide an ideal scattering medium with a significantly high-reflectance stopband which facilitates resonance feedback for random lasing action. By doping organic dye molecules into the Artemia eggshells, random lasers are realized by optical pumping with a threshold of 79 μJ/mm2, and a quality (Q) factor of 2328. In comparison with other works on random lasers from natural photonic crystals such as butterfly wings, our random lasers demonstrate a significantly lower lasing threshold and a comparable Q factor. Our results indicate that the natural inverse photonic glass structure is not only served as an effective scattering medium for random lasing but also paves a novel approach in designing and fabricating bio-controlled photonic devices.