Introduction Weaning predictors can help liberate patients in a timely manner from mechanical ventilation. Ventilatory equivalent for oxygen (VEqO 2 ), a surrogate for work of breathing and a measure of the efficiency of breathing, may be an important noninvasive alternative to other weaning predictors. Our study’s purpose was to observe any differences in VEqO 2 between extubation outcome groups. Methods Employing a metabolic cart, oxygen consumption ( V ˙ O 2 ), minute volume (VE), tidal volume (VT), and breathing frequency were recorded during a spontaneous breathing trial (SBT) to calculate VEqO 2 and the rapid shallow breathing index (RSBI) in 34 adult participants in the intensive care unit. Five-breath means of VEqO 2 and the RSBI collected throughout the SBT were examined between SBT pass and fail groups and extubation pass and fail groups using the Mann–Whitney U test with p < 0.05. Results Data from 31 participants were analyzed between SBT outcome groups. Data from 20 participants were examined for extubation outcome after a successful SBT. Median (interquartile range) VEqO 2 was not different between extubation groups. Participants who passed the SBT had a higher median VEqO 2 than those who did not at the midpoint (25.3 L/L V ˙ O 2 [22–33 L/L V ˙ O 2 ] vs. 23.7 L/L V ˙ O 2 [18–24 L/L V ˙ O 2 ], p = 0.035) and at the end (25.5 L/L V ˙ O 2 [23–34 L/L V ˙ O 2 ] vs. 21.3 L/L V ˙ O 2 [20–24 L/L V ˙ O 2 ], p = 0.017) of the SBT. Discussion VEqO 2 may show differences in SBT outcomes, but not differences between extubation outcomes. VEqO 2 may be able to detect differences in work during an SBT, but may not be able to predict change in workload in the respiratory system after extubation. The small sample size may also have prevented any differences in extubation outcomes to be shown. Conclusion VEqO 2 was higher in patients that passed their SBT. VEqO 2 was not useful in identifying extubation suc...