New analog α–amino phosphate series with high yield through an effective and environmentally friendly protocol using the PEG‐400 catalyst via Kabachnik‐Fields has been reported. They were performed to screen antimicrobial activities by the dish diffusion method, anticancer against MCF‐7, A‐549, and HeLa human cancer cell lines by MTT assay, and carried out in silico molecular docking by Avogadro, AutoDockTools, Discovery Studio 2019 Client, and Molegro Molecular Viewer packages. The 3c and 3h displayed excellent inhibition against Candida albicans and Saccharomyces cerevisiae fungi, respectively. The molecular docking model indicated the reasonable explanations between the receptor and bioactive compounds in vitro of 3c, 3 h, and 3b. The 3c was shown as an excellent inhibitor against Candida albicans, which was a new result in vitro and in silico molecular docking model. The 3c, 3 f, and 3i pointed out excellent inhibitions against HeLa cell lines and new anticancer results of α–amino phosphate compounds. The docking studies of structures against receptors of three human cancer cell lines were conducted and recommended that the hydrogen bonds only formed from active sites of receptors to oxygen atom of the ethoxy group, nitrogen and hydrogen atoms of N−H group, oxygen atom of the P=O double bond group, and the fluorine atoms of the CF3 group in 3i for calculated docking of the receptors of bacteria, fungi, and cancer cell lines to all ligands.

Plastic waste accumulation is a current societal crisis. Although replacing nondegradable plastics with biodegradable alternatives is one solution to this problem, conventional biodegradable plastics have low mechanical performance and require fastidious decomposition conditions. Consequently, fulfilling the industrial requirements of processability, end-use applicability, and post-use biodegradability is difficult. Therefore, integrating mechanical robustness and enhanced degradability into a single material is critical. Herein, we introduce a fully biomass-derived poly­(butylene adipate-co-furanoate) (PBAF) composite with sulfated chitin nanowhiskers prepared by in situ polymerization. This approach efficiently disperses the nanofiller in the polymer matrix and creates beneficial interactions between the nanofiller and the furan rings of the polymer, resulting in excellent material properties. A PBAF composite film loaded with 0.1 wt % nanofiller is as strong as a nondegradable engineering plastic (i.e., poly­(ethylene terephthalate)) and exhibits higher tensile strength (1.6-fold), tear toughness (1.4-fold), and degradation rate (1.7-fold) than neat PBAF. A structure–performance relationship study revealed that the nanofiller is accommodated close to the furan rings of the polymer, which results in noticeable segmental mobility and structural change, whereas the benzene rings of conventional poly­(butylene adipate-co-terephthalate) show negligible change due to its sturdy crystalline phase. The developed all-organic composite is a sustainable alternative to conventional plastics.

Controlled-release fertilizers (CRFs) are a next-generation type of fertilizers, with several advantages over conventional fertilizer. However, using non-degradable and petroleum-based materials in the fabrication of CRFs possess considerable threat to agricultural soils and the environment. Therefore, this study aimed to develop a highly biodegradable, nontoxic, and biocompatible CRFs based on calcium alginate (CaAlg) beads. The results showed that the sphericity of the beads increased with decreasing CaCl2 concentration and increasing gelation time. Additionally, there was a significant decrease in the viscosity of sodium alginate (NaAlg) suspension with increasing concentration of urea. Moreover, there was an increase in the urea loading (UL) efficiency and a decrease in the urea release rate of the beads with increasing concentration of CaCl2. Furthermore, carrots grown in the control soil and soil containing urea were larger compared with those grown in soils containing CRF, indicating the controlled release of nitrogen by the CRF. Adding humic acid (HA), poly vinyl acid (PVA), and citric acid to the suspension increased the stability and improved the urea release profile of the CRF. Overall, the fabrication process is easy and could be applied for the mass production of CRFs.