Cultural Effects on Sorghum Varieties Grown, Traits Preferred, and Seed Management Practices in Northern Ethiopia. Agrobiodiversity is fundamentally shaped by farmers’ preferences and management practices, and these are again shaped by the farmers’ social and cultural background. This study investigates variety preferences and seed management practices in the crop sorghum (Sorghum bicolor) among the Kunama and the Tigrayan ethnolinguistic groups living side by side in Northern Ethiopia. Surveys were conducted in 10 villages located in two districts inhabited by the two ethnolinguistic groups and analyzed using descriptive and multinominal analysis. We find important differences in varieties grown across the ethnolinguistic groups, but we also find that ethnicity and geographic proximity interact and affect trait preference and seed management practices. Altogether, 22 varieties are cultivated, and few farmers cultivated improved varieties, especially among the Kunama. Respondents considered use traits as important as agronomic traits when selecting sorghum varieties. Notably, preferred use traits were not limited to food (e.g., construction materials were important for the Kunama), and preferred agronomic traits were not focused on drought resistance. Timing of seed selection, seed selection criteria (e.g., panicle size and color), and seed storage practices differed among the ethnic groups. Understanding cultural and social preferences towards sorghum varieties, their traits, and the criteria used for seed management is crucial for the success of crop breeding programs, climate change adaptation policies, and development interventions.