Objective An already overwhelmed health system with many sporadic outbreaks is now threatened by the COVID-19 epidemics. Person-to-person transmission is currently ongoing in the country, making it necessary to control the disease. To guarantee successful disease control, the knowledge, attitudes and, practices people hold towards the disease play an integral role. Therefore, the aim of this study was to determine the knowledge, attitude, and practice towards COVID-19 among antenatal care clients of Adama Hospital Medical College, Adama, Ethiopia. Results A cross-sectional study was conducted from May 6, 2021, to May 31, 2021. Among the 292 study participants, 222 (75.3%) had good knowledge and 70 (24%) moderate knowledge status. Significant number of respondents 131 (44.9%) had neutral attitude while 159 (54.5%) had positive attitude. The prevalence of poor practice was 61 (20.9%). Majority of the respondents, 136 (46.6%) had moderate practice level.