24In this study, a Quality by Design (QbD) approach was used to identify the effect of formulation 25 parameters in a twin screw wet extrusion granulation process for the manufacturing of showed that all formulation parameters affect the dependent variables significantly. The 33 enhanced dissolution rates were attributed not only to the IBU particle size reduction and 34 adsorption in the porous inorganic network but also to the high specific surface area of the 35 produced granules. Dynamic vapour sorption showed increased water absorption for granules 36 with small particle size distribution and high specific surface area.

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