Sulfonylureas represent one of the largest herbicide groups that have been widely used since 1980s. Their continuous use has resulted in development of sulfonylurea resistance in weeds. The aim of this research was to investigate options to manage putative sulfonylurea-resistant chickweed in barley stands and to evaluate the effect of chickweed and its management on barley yield. A field experiment was arranged as a randomized complete block design and included 14 herbicide treatments applied at two different times. Tribenuron-methyl (sulfonylurea) affected minimal control of chickweed. A bromoxynil-ioxynil (photosystem II inhibitor) mix did not control chickweed efficiently. However, nearly total control was achieved with fluroxypyr, mecoprop, and their mixtures (synthetic auxins and photosystem II inhibitors). Chickweed had no effect on barley yield whether controlled or uncontrolled. Therefore, further evaluation of the chickweed management threshold would be needed. It seems that even in the boreal region, typified by a cold climate, limited solar radiation, a very short growing season, and relatively low-intensity cropping systems, unilateral use of sulfonylureas might lead to herbicide resistance. Although resistant weed populations can be controlled with herbicides of groups other than the sulfonylureas, this represents an increasing problem when planning weed management, especially when including sulfonylurea-resistant crops.