Objective The aim of this study was to determine the concentration of fluoride ions present in various solvent solutions and compare it to the label amount of fluoride concentration. Material and methods The gel containing amine fluoride and sodium fluoride was compared to gel containing sodium fluoride only. The solvents used in this study were distilled water, redistilled water, tap water, 0.9% sodium chloride solution and the artificial saliva. The amount of fluoride ion (F - ) was determined by the use of fluoride ion-selective electrode. The ANOVA and the Post hoc Tukey’s test were used. The significance level was α = 5%. Results The differences between F - ion release in various solvents were statistically significant (p < 0.05). The F - ion concentrations measured in both gels’ redistilled water solutions were higher than the label concentration. There was a significant difference in fluoride ion release in sodium fluoride only gel solutions. Fluoride ion release was significantly different in combined fluoride gel solutions. Conclusions Amine fluorides do not interact with other ions present in the solution, whereas F - ion release from sodium fluoride alters when other ions are dissolved in the same solution. Amine fluorides deliver F - ions for caries prevention more efficiently.