Background:The aim of the study was to evaluate the patients who underwent minimally invasive cardiac surgery and percutaneous internal jugular vein catheterization in our center, and to discuss the catheterization results and complications in the literature. Materials and Methods:Between January 2015 and September 2019, 70 female (59.3%) and 48 (40.7%) male patients, who underwent minimally invasive cardiac surgery and percutaneous internal jugular vein cannulation in our center, had a mean age of 37.2±14.5 (19-74 years), data of 118 cases were evaluated retrospectively. It was noted that 17 F jugular venous catheter was placed in patients with body surface area (BSA) <1.87, and 19 F venous catheter was placed in patients with (BSA) >1.87. Cannula positions and echocardiographic findings of the patients during cannulation were evaluated with transesophageal echocardiography (TEE).Results: All surgical interventions were performed minimally invasively by thoracotomy. Since the adequate surgical field of vision could not be achieved in 3 (2.5%) of the patients, the operation was reverted to sternotomy. No mortality due to cannulation was observed in any of the patients. Local hematoma (1.6%) developed due to carotid artery puncture in 2 patients, transient atrial fibrillation (1.6%) in 2 patients, and pneumothorax (0.8%) in one patient. Conclusion:Minimally invasive cardiac surgical interventions have become popular nowadays and their importance has increased due to reasons such as faster recovery of patients, less complications, and smaller surgical incision area. Internal jugular cannulation is required in minimally invasive cardiac surgery procedures. In order to avoid possible complications in the percutaneous cannulation process and therefore to reduce mortality, it is very important that cannulation procedures be performed by an experienced team and evaluated with TEE during this time.