The relationship between neighborhood food environment and childhood obesity is complex and not yet well defined by current research in China, especially when considering the integrated effects with other relative factors. The main purpose of this article is to introduce a framework of children’s weight status, based on their neighborhood food environment, and to identify the impact of food environment on the children’s BMI and potential pathways. The participants of this cross-sectional study were students aged 8–16.5 years old and their parents. Two conceptual frameworks were tested using the structural equation modeling method, and two models were extracted. Model B added the neighborhood food environment based on model A. By comparing the two models, the neighborhood environment was potentially correlated with the children’s BMI directly and may have a positive impact on unhealthy-food eating behaviors, which were positively associated with the children’s BMI. The results suggest that the focus should be placed on the integrated effects of the potential risk factors of childhood obesity, based on considering the neighborhood food environment, which may relate to children’s unhealthy-food eating behaviors and weight status.