Nowadays, clean and high-power generation is essential matters worldwide. To be improved and optimized, power plants require accurate models that can be introduced to process simulators. There is various commercial software for industrial simulation which is not accessible to everyone. The open-source DWSIM process simulator is the first chemical engineering code that offers many tools for the better study of industrial plants. In this paper, we employ DWSIM software to simulate a combined cycle gas turbine (CCGT) power plant under design conditions for three cases. The generic models are predicted for multistage compressors and compressor maps. In the first case, two models developed in ASPEN HYSYS and GateCycle will be considered. The achieved results by DWSIM are acceptably comparable for thermal efficiency and power generation. The DWSIM result is 3.5% lower than the ASPEN HYSYS for thermal efficiency, and the power generation is completely the same. In the second case, rigorous simulation was carried out using actual field data from the local CCGT power plant. The DWSIM outcomes are very close to the practical data. The power generation of GT and CC is very close; the variety is nearly 0.45%. In the third case, the simulation of CCGT with a cogeneration system is precisely accomplished, and the outcomes of DWSIM are shown in excellent agreement. The DWSIM prediction shows lower values by 0.26%, 4.79%, and 0.72% for the HP turbine, LP turbine, and plant net power, respectively.