No abstract

Glioblastoma multiforme (GBM), the most common malignant brain tumor, universally carries a poor prognosis. Despite aggressive multimodality treatment, the median survival is ~18–20 months, depending on molecular subgroups. A long history of observations suggests antitumor effects of bacterial infections against malignant tumors. The present review summarizes and critically analyzes the clinical data providing evidence for or against the survival benefit of post-operative bacterial infections in GBM patients. Furthermore, we explore the probable underlying mechanism(s) from basic science studies on the topic. There are plausible explanations from immunobiology for the mechanism of the “favorable effect” of bacterial infections in GBM patients. However, available clinical literature does not provide a definitive association between postoperative bacterial infection and prolonged survival in GBM patients. The presently available, single-/multi-center and national database retrospective case-control studies on the topic provide conflicting results. A prospective randomized study on the subject is clearly not possible. Immunobiology literature supports development of genetically modified bacteria as part of multimodal regimen against GBM.

PdZn mixed oxides are precursors for the formation of intermetallic PdZn phases, which show improved catalytic performance for methanol steam reforming. In this work we have prepared mixed oxides (Pd x Zn 1-x O) that span a range of compositions around the tetragonal PdZn 1:1 L 10 phase (x = 0.25, 0.5 and 0.75). We find that Pd +2 can be isomorphously substituted into hexagonal ZnO and likewise Zn +2 can also be substituted within tetragonal PdO. Our results show that the mixed oxide has a composition Pd 0.75 Zn 0.25 O within the tetragonal PdO lattice with a slight contraction in unit cell volume. The results are relevant for understanding the enhanced sensing properties of ZnO and the nature of the oxide precursors for the synthesis of intermetallic PdZn nanoparticles for heterogeneous catalysis.

Introduction Matching into an orthopaedic surgery residency program presents a challenging accomplishment for applicants to achieve in any given year. Due to the profound changes to the application process caused by the coronavirus disease 2019 (COVID-19) pandemic it was theorized that there would be a change in the number of graduates matching close to their home medical school region, state, and program. Methods Orthopaedic surgery residency program Web sites and social media accounts were accessed to elucidate current resident data, including graduates' medical school, and geographical location of their school. Chi-square analysis was performed to identify trends in current residents matching within their home program, state, and region associated with the 2021 orthopaedic match. These numbers were compared with previous year's successful applicants. Results In 2021, a significant 4.4% (p=0.02) increase in successful matches within applicants' home states occurred (33.4% vs. 37.8%) and home programs (p<0.001) when compared with previous years (21.2% vs. 27.4%). However, in 2021, there was no significant change in home region matching (p=0.56) with 60% of successful matches occurring in home regions. This was statistically consistent with what was observed in previous years (61.4%). Conclusion The COVID-19 pandemic was associated with restrictions in travel and interview options resulting in a significant increase in the number of orthopaedic applicants who matched into their home program, or at programs in their home state compared with previous years. Although no statistically significant regional change occurred during the 2021 match, it remains the leading predictor of where successful applicants will match. With many unknowns related to the upcoming match cycles it is important for applicants and programs to have a general idea of recent trends and outcomes to best focus their efforts, especially if diversity and minority inclusion are considered in highly competitive specialties like orthopaedic surgery.