Mine workers operate heavy equipment while experiencing varying psychological and physiological impacts caused by fatigue. These impacts vary in scope and severity across operators and unique mine operations. Previous studies show the impact of fatigue on individuals, raising substantial concerns about the safety of operation. Unfortunately, while data exist to illustrate the risks, the mechanisms and complex pattern of contributors to fatigue are not understood sufficiently, illustrating the need for new methods to model and manage the severity of fatigue’s impact on performance and safety. Modern technology and computational intelligence can provide tools to improve practitioners’ understanding of workforce fatigue. Many mines have invested in fatigue monitoring technology (PERCLOS, EEG caps, etc.) as a part of their health and safety control system. Unfortunately, these systems provide “lagging indicators” of fatigue and, in many instances, only provide fatigue alerts too late in the worker fatigue cycle. Thus, the following question arises: can other operational technology systems provide leading indicators that managers and front-line supervisors can use to help their operators to cope with fatigue levels? This paper explores common data sets available at most modern mines and how these operational data sets can be used to model fatigue. The available data sets include operational, health and safety, equipment health, fatigue monitoring and weather data. A machine learning (ML) algorithm is presented as a tool to process and model complex issues such as fatigue. Thus, ML is used in this study to identify potential leading indicators that can help management to make better decisions. Initial findings confirm existing knowledge tying fatigue to time of day and hours worked. These are the first generation of models and future models will be forthcoming.